Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535778 | 0.88 | KAT2B (0.39) | TMEM97SIGMAR1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL9533699 | 0.85 | ADRA2A (0.47) | TMEM97SIGMAR1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL9535436 | 0.85 | PRMT5 (0.41) | SMN1; SMN2NPC1RAB9AL3MBTL1HTR1A | |
| SCHEMBL9535741 | 0.80 | TMEM97 (0.42) | TMEM97SIGMAR1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL9536218 | 0.79 | L3MBTL1 (0.39) | TMEM97SIGMAR1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL9380075 | 0.75 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CDRD1 | |
| SCHEMBL9533864 | 0.74 | ADRA2A (0.56) | TMEM97SIGMAR1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL9534803 | 0.73 | KAT2B (0.40) | TMEM97SIGMAR1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL9534397 | 0.73 | HTR6 (0.37) | ADRA2AADRA2BADRA2CHRH1 | |
| SCHEMBL9534388 | 0.73 | HTR6 (0.37) | ADRA2AADRA2BADRA2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384676-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-11-10 | — | — | EP | disclosed |
| US-4981849-A | OBESITY, DIABETES, CARDIOVASCULAR DISORDERS, DEPRESSION | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384676-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |