Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533699 | 0.90 | ADRA2A (0.47) | KEAP1NFE2L2TMEM97SIGMAR1ADORA1 | |
| SCHEMBL9535778 | 0.81 | KAT2B (0.39) | KEAP1NFE2L2TMEM97SIGMAR1ADORA1 | |
| SCHEMBL9534814 | 0.80 | ADRA2A (0.42) | L3MBTL1KEAP1NFE2L2NPC1RAB9A | |
| SCHEMBL9534051 | 0.79 | ADRA2A (0.51) | L3MBTL1CYP1A2SMN1; SMN2GAA | |
| SCHEMBL9534421 | 0.72 | HTR6 (0.40) | LMNAGAA | |
| SCHEMBL9534428 | 0.72 | HTR6 (0.40) | LMNAGAA | |
| SCHEMBL9536306 | 0.71 | ADRA2A (0.46) | CYP1A2GAA | |
| SCHEMBL9379818 | 0.67 | ADRA2A (0.51) | L3MBTL1RAB9AADORA1LMNASMN1; SMN2 | |
| Benzyl Benzylcarbamate SCHEMBL1136818 | 0.65 | PLAU (0.70) | KEAP1NFE2L2LMNASMN1; SMN2PLAU | |
| SCHEMBL26630611 | 0.64 | TMEM97 (0.50) | L3MBTL1NPC1RAB9ATMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384676-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-11-10 | — | — | EP | disclosed |
| US-4981849-A | OBESITY, DIABETES, CARDIOVASCULAR DISORDERS, DEPRESSION | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384676-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |