Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535094 | 0.84 | ALDH1A1 (0.44) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9535666 | 0.82 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9533677 | 0.72 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9535778 | 0.70 | KAT2B (0.39) | ADORA1TMEM97SIGMAR1KEAP1NFE2L2 | |
| SCHEMBL9533309 | 0.69 | ADRA1D (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Benzyl Benzylcarbamate SCHEMBL1136818 | 0.64 | PLAU (0.70) | KEAP1NFE2L2LMNASMN1; SMN2ALDH1A1 | |
| Benzyl Benzylcarbamate SCHEMBL19810513 | 0.63 | PLAU (0.68) | KEAP1NFE2L2LMNASMN1; SMN2ALDH1A1 | |
| Benzyl Benzylcarbamate SCHEMBL9998166 | 0.63 | PLAU (0.68) | KEAP1NFE2L2LMNASMN1; SMN2ALDH1A1 | |
| Benzyl Benzylcarbamate SCHEMBL28413454 | 0.63 | PLAU (0.68) | KEAP1NFE2L2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12203724 | 0.62 | SMN1; SMN2 (0.66) | L3MBTL1NPC1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384677-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-12-01 | — | — | EP | disclosed |
| US-4981848-A | CARDIOVASCULAR, HYPOTENSIVE, ANTIDEPRESSANT | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |