Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 4/20 | 0.31 |
| ▸ | CNR2 | P34972 | 4/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535251 | 0.82 | — | — | |
| SCHEMBL16287745 | 0.79 | HCAR2 (0.40) | KEAP1NFE2L2HCAR2MAPTCNR1 | |
| SCHEMBL16289019 | 0.75 | HCAR2 (0.41) | KEAP1NFE2L2HCAR2MAPTCNR1 | |
| SCHEMBL8835495 | 0.72 | PGR (0.34) | KEAP1NFE2L2HCAR2MAPTCNR1 | |
| SCHEMBL31681514 | 0.72 | HCAR2 (0.55) | KEAP1NFE2L2HCAR2MAPTCNR1 | |
| SCHEMBL9534115 | 0.70 | DNTT (0.36) | KEAP1NFE2L2HCAR2MAPTCNR1 | |
| SCHEMBL9306488 | 0.70 | ALDH1A1 (0.42) | KEAP1NFE2L2HCAR2 | |
| SCHEMBL16287316 | 0.70 | HCAR2 (0.43) | KEAP1NFE2L2HCAR2MAPT | |
| SCHEMBL15423612 | 0.70 | FAAH (0.31) | — | |
| SCHEMBL11621723 | 0.69 | PGR (0.36) | KEAP1NFE2L2HCAR2MAPTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362816-B1 | Cyclopenteneheptanoic acid derivatives and method of preparation thereof | SEARLE & CO (US) | 1993-11-18 | — | — | EP | disclosed |
| US-4952710-A | STARTING MATERIAL FOR OPTICALLY ACTIVE PROSTAGLANDINS | G. D. SEARLE & CO. (US) | 1990-08-28 | — | — | US | disclosed |
| EP-0362816-A1 | Cyclopenteneheptanoic acid derivatives and method of preparation thereof | G.D. Searle & Co. (US) | 1990-04-11 | — | — | EP | disclosed |