Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1498698 | 0.76 | PNP (0.44) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL6475571 | 0.74 | IDO1 (0.46) | GAAMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL29181814 | 0.71 | IDO1 (0.44) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL15280424 | 0.70 | CA2 (0.61) | LMNAGAAMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL28167008 | 0.70 | PNP (0.42) | GAAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL21401837 | 0.69 | CHRM2 (0.49) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL9538789 | 0.69 | ALDH1A1 (0.46) | GAAMEN1KMT2AALDH1A1IDO1 | |
| SCHEMBL9537893 | 0.69 | ALDH1A1 (0.41) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL9537123 | 0.69 | SMN1; SMN2 (0.46) | IDO1EP300KAT8KDM4ESMN1; SMN2 | |
| SCHEMBL11010861 | 0.68 | GAA (0.49) | LMNAGAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |