Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 7/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888497 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1SYKALOX15AURKB | |
| SCHEMBL6475571 | 0.76 | IDO1 (0.46) | SMN1; SMN2IDO1EP300KAT8KDM4E | |
| SCHEMBL2750449 | 0.71 | KDM4E (0.56) | SMN1; SMN2IDO1L3MBTL1SYKAURKB | |
| SCHEMBL28306283 | 0.71 | ALOX15 (0.64) | SMN1; SMN2L3MBTL1ALOX15KDM4E | |
| SCHEMBL29181814 | 0.70 | IDO1 (0.44) | SMN1; SMN2IDO1L3MBTL1EP300KAT8 | |
| SCHEMBL23837621 | 0.70 | L3MBTL1 (0.42) | SMN1; SMN2L3MBTL1SYKAURKBINCENP | |
| SCHEMBL9379876 | 0.70 | ALOX15 (0.55) | SMN1; SMN2L3MBTL1ALOX15KDM4E | |
| SCHEMBL9539903 | 0.70 | L3MBTL1 (0.42) | SMN1; SMN2L3MBTL1SYKAURKBINCENP | |
| SCHEMBL7076400 | 0.69 | IDO1 (0.40) | SMN1; SMN2IDO1EP300KAT8 | |
| SCHEMBL9536141 | 0.69 | LMNA (0.39) | SMN1; SMN2IDO1EP300KAT8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |