Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535069 | 0.90 | MTNR1A (0.43) | MTNR1AMTNR1BKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL341538 | 0.83 | KEAP1 (0.47) | MTNR1AMTNR1BKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL28676841 | 0.77 | KDM4E (0.49) | MTNR1AMTNR1BKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL24708884 | 0.76 | MTNR1B (0.53) | MTNR1AMTNR1B | |
| SCHEMBL10654450 | 0.72 | MTNR1A (0.44) | MTNR1AMTNR1BKDM4ESMN1; SMN2TP53 | |
| SCHEMBL11165063 | 0.72 | SMN1; SMN2 (0.56) | KDM4EPOLBSMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL3426911 | 0.70 | MTNR1B (0.49) | MTNR1AMTNR1BTP53ALDH1A1 | |
| SCHEMBL3963942 | 0.70 | SMN1; SMN2 (0.50) | KDM4EPOLBSMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL29698599 | 0.70 | SMN1; SMN2 (0.54) | KDM4EPOLBSMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL5694511 | 0.69 | SMN1; SMN2 (0.49) | KDM4EPOLBSMN1; SMN2AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| EP-0092380-B1 | ANTIALLERGIC 4H-FURO(3,2-B)INDOLES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4596814-A | Antiallergens | WARNER-LAMBERT COMPANY (US) | 1986-06-24 | — | — | US | disclosed |
| US-4503236-A | Antiallergic 4Hfuro[3,2-b]indoles | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0092380-A2 | Antiallergic 4H-furo(3,2-b)indoles and their production | WARNER-LAMBERT COMPANY (US) | 1983-10-26 | — | — | EP | disclosed |