Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9040140 | 0.83 | ADORA2A (0.51) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL9039440 | 0.83 | ADORA2A (0.51) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL9038372 | 0.80 | TAS2R14 (0.46) | TAS2R14ATAD2ADORA2BPIK3CDADORA3 | |
| SCHEMBL10542962 | 0.79 | CFTR (0.54) | ADORA2BADORA2AADORA1PDE4APDE4B | |
| SCHEMBL9038623 | 0.79 | PDE1A (0.54) | ADORA2BADORA2AADORA1PDE4APDE4B | |
| SCHEMBL9536102 | 0.79 | TAS2R14 (0.45) | TAS2R14ATAD2ADORA2BPIK3CDADORA3 | |
| SCHEMBL9039076 | 0.79 | TAS2R14 (0.48) | TAS2R14ATAD2ADORA2BPIK3CDADORA3 | |
| SCHEMBL9038342 | 0.77 | ADORA2B (0.52) | ADORA2BADORA3LMNAPOLBALDH1A1 | |
| SCHEMBL9972909 | 0.77 | LMNA (0.48) | TAS2R14ADORA2BPIK3CDADORA3ADORA2A | |
| SCHEMBL9972893 | 0.77 | TAS2R14 (0.43) | TAS2R14ATAD2ADORA2BPIK3CDADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243311-A2 | Pyrido[2,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1987-10-28 | — | — | EP | claimed |
| JP-63045279-A | — | — | None | — | — | JP | disclosed |
| EP-0243311-B1 | Pyrido[2,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |
| US-4808587-A | ANTIALLEGENS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| JP-S6345279-A | NOVEL PYRIDO(2,3-D)PYRIMIDINE DERIVATIVE, PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND | NIPPON ZOKI PHARMACEUT CO LTD | 1988-02-26 | — | — | JP | disclosed |
| EP-0243311-A2 | Pyrido[2,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1987-10-28 | — | — | EP | disclosed |