Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535642 | 0.84 | SMN1; SMN2 (0.43) | GAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9537277 | 0.80 | CNR1 (0.36) | GAAALDH1A1BACE1MAPTNPSR1 | |
| SCHEMBL9538789 | 0.79 | ALDH1A1 (0.46) | GAAALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL9538832 | 0.68 | GAA (0.43) | GAAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3788490 | 0.68 | GAA (0.40) | GAAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9536285 | 0.67 | SLC2A1 (0.38) | GAAALDH1A1MAPTHPGD | |
| SCHEMBL3038603 | 0.67 | GAA (0.69) | GAAALDH1A1MAPTMAPK1 | |
| SCHEMBL17501659 | 0.67 | TRPC5 (0.42) | GAAALDH1A1NPC1KMT2AMAPT | |
| SCHEMBL6863788 | 0.66 | GAA (0.42) | GAAALDH1A1SMN1; SMN2POLBHPGD | |
| SCHEMBL16113498 | 0.66 | GAA (0.45) | GAAALDH1A1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |