Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.38 |
| ▸ | TUBB | P07437 | 4/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536290 | 0.84 | GAA (0.41) | SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL9537277 | 0.84 | CNR1 (0.36) | SMN1; SMN2GAAALDH1A1L3MBTL1CNR1 | |
| SCHEMBL9538789 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2GAAALDH1A1CYP19A1L3MBTL1 | |
| SCHEMBL9535895 | 0.71 | CNR1 (0.41) | SMN1; SMN2GAAALDH1A1CNR1CNR2 | |
| SCHEMBL11442618 | 0.69 | HTR2A (0.43) | GAAALDH1A1CYP19A1TUBB4ATUBB | |
| SCHEMBL9538832 | 0.69 | GAA (0.43) | SMN1; SMN2GAAALDH1A1TSHRGPR55 | |
| SCHEMBL3788490 | 0.69 | GAA (0.40) | SMN1; SMN2GAAALDH1A1TSHRCNR1 | |
| SCHEMBL10132616 | 0.69 | TUBB4A (0.48) | GAAALDH1A1TUBB4ATUBBTUBA3C | |
| SCHEMBL9536285 | 0.68 | SLC2A1 (0.38) | GAAALDH1A1LMNAMAPT | |
| SCHEMBL3038603 | 0.68 | GAA (0.69) | GAAALDH1A1CYP19A1TSHRGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |