Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 4/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536299 | 0.87 | MAPT (0.39) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9533850 | 0.82 | ALDH1A1 (0.33) | ALDH1A1EGLN1LMNAGAAMAPK1 | |
| SCHEMBL9767646 | 0.75 | ALDH1A1 (0.34) | ALDH1A1EGLN1LMNAGAAMAPK1 | |
| SCHEMBL9555801 | 0.75 | ALDH1A1 (0.47) | ALDH1A1LMNAGAAMAPK1KMT2A | |
| SCHEMBL9533735 | 0.71 | LMNA (0.36) | ALDH1A1LMNAMAPK1KMT2AMEN1 | |
| SCHEMBL9348254 | 0.70 | PGR (0.43) | ALDH1A1EGLN1KMT2AMEN1 | |
| SCHEMBL9629039 | 0.68 | EGLN1 (0.34) | ALDH1A1EGLN1GAAKMT2AMEN1 | |
| SCHEMBL28759170 | 0.67 | ALDH1A1 (0.40) | ALDH1A1LMNAGAAKMT2AMEN1 | |
| SCHEMBL9470178 | 0.67 | MAOA (0.41) | ALDH1A1LMNAGAAKMT2AMEN1 | |
| SCHEMBL9629835 | 0.66 | EGLN1 (0.34) | ALDH1A1EGLN1GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049671-A | Hepatitis, AIDS | BURROUGHS WELLCOME CO. (US) | 1991-09-17 | — | — | US | disclosed |
| US-5045542-A | Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| US-5011860-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases | SCHERING CORPORATION (US) | 1991-04-30 | — | — | US | disclosed |
| US-4882332-A | Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4866061-A | TREATMENT OF ALLERGIC REACTIONS, ULCERS, INFLAMMATION | SCHERING CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4760073-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents | SCHERING CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0241291-A2 | Aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |