Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536147 | 0.83 | HTT (0.44) | MAPK1KDM4EMITFALDH1A1LMNA | |
| SCHEMBL9537569 | 0.83 | HTT (0.44) | MAPK1KDM4EMITFALDH1A1LMNA | |
| SCHEMBL9535977 | 0.83 | ALDH1A1 (0.40) | MAPTTP53ATMKDM4EALDH1A1 | |
| SCHEMBL9535963 | 0.82 | LMNA (0.40) | CCR2EDNRAMAPTKDM4ELMNA | |
| SCHEMBL9535154 | 0.79 | PLA2G2A (0.46) | EDNRBEDNRA | |
| SCHEMBL23760000 | 0.77 | CCR2 (0.63) | CCR2EDNRBEDNRAHDAC1HDAC6 | |
| SCHEMBL9538638 | 0.77 | CCR2 (0.77) | CCR2EDNRBEDNRAHDAC1HDAC6 | |
| SCHEMBL9826373 | 0.76 | CCR5 (0.34) | MAPTTP53PLK4AURKAROCK2 | |
| SCHEMBL9535059 | 0.75 | ALDH1A1 (0.38) | HDAC1HDAC6MAPTMAPK1KDM4E | |
| SCHEMBL9536287 | 0.73 | KDM4E (0.47) | EDNRAMAPTKDM4EALDH1A1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | claimed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |