Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537927 | 0.91 | LMNA (0.55) | LMNAENPP2TP53MAPTSMN1; SMN2 | |
| SCHEMBL9536863 | 0.89 | TP53 (0.54) | LMNAENPP2TP53MAPTHTT | |
| SCHEMBL9535367 | 0.87 | SLC6A9 (0.58) | LMNAENPP2TP53MAPT | |
| SCHEMBL9537835 | 0.86 | SSTR5 (0.59) | LMNATP53MAPTHTTSMN1; SMN2 | |
| SCHEMBL9539234 | 0.85 | LMNA (0.58) | LMNAENPP2TP53MAPTHTT | |
| SCHEMBL9535787 | 0.84 | KDM4E (0.55) | LMNAENPP2TP53MAPTSMN1; SMN2 | |
| SCHEMBL9538036 | 0.82 | CCR3 (0.48) | LMNAENPP2TP53MAPTSMN1; SMN2 | |
| SCHEMBL9535014 | 0.82 | SLC6A9 (0.55) | LMNAENPP2HTTSMN1; SMN2 | |
| SCHEMBL9537207 | 0.81 | SLC6A9 (0.47) | LMNAENPP2TP53MAPTHTT | |
| SCHEMBL9536027 | 0.81 | SLC6A9 (0.67) | LMNAENPP2TP53MAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |