Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537927 | 0.92 | LMNA (0.55) | KDM4ESMN1; SMN2ENPP2CCR3SLC6A9 | |
| SCHEMBL9537696 | 0.87 | HRH1 (0.60) | KDM4ESMN1; SMN2ENPP2SLC6A9LMNA | |
| SCHEMBL9535367 | 0.87 | SLC6A9 (0.58) | ENPP2CCR3SLC6A9LMNAHTR3E | |
| SCHEMBL9536863 | 0.87 | TP53 (0.54) | SMN1; SMN2ENPP2CCR3SLC6A9LMNA | |
| SCHEMBL9538036 | 0.85 | CCR3 (0.48) | KDM4ESMN1; SMN2ENPP2CCR3SLC6A9 | |
| SCHEMBL9536724 | 0.84 | LMNA (0.58) | SMN1; SMN2ENPP2LMNASIGMAR1ALDH1A1 | |
| SCHEMBL9536027 | 0.84 | SLC6A9 (0.67) | ENPP2CCR3SLC6A9LMNASIGMAR1 | |
| SCHEMBL9537207 | 0.84 | SLC6A9 (0.47) | KDM4EENPP2CCR3SLC6A9LMNA | |
| SCHEMBL10547503 | 0.84 | SLC6A9 (0.46) | KDM4ESMN1; SMN2ENPP2CCR3SLC6A9 | |
| SCHEMBL9538101 | 0.83 | TP53 (0.47) | KDM4ESMN1; SMN2ENPP2SLC6A9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |