Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536807 | 0.93 | SSTR5 (0.50) | MEN1KMT2ALMNAHTTCYP1A2 | |
| SCHEMBL9536155 | 0.86 | USP2 (0.42) | MEN1KMT2ANPSR1HTTALDH1A1 | |
| SCHEMBL9537145 | 0.86 | SLC6A9 (0.53) | MEN1KMT2ANPSR1HTTTDP1 | |
| SCHEMBL9539219 | 0.85 | HRH1 (0.42) | MEN1KMT2ANPSR1LMNAALPL | |
| SCHEMBL9538985 | 0.85 | GRIN2B (0.45) | LMNAGRIN2BGRM2CARM1PRMT6 | |
| SCHEMBL9538639 | 0.84 | SSTR5 (0.48) | MEN1KMT2ALMNAHTTCYP1A2 | |
| SCHEMBL8565529 | 0.84 | GRIN2B (0.38) | MEN1KMT2ANPSR1LMNAALPL | |
| SCHEMBL9537110 | 0.83 | SSTR5 (0.49) | MEN1KMT2ALMNAHTTCYP1A2 | |
| SCHEMBL5626341 | 0.83 | MEN1 (0.66) | MEN1KMT2ANPSR1LMNAPKM | |
| SCHEMBL9537238 | 0.83 | KCNH2 (0.43) | LMNAHTTCYP2D6SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |