Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536624 | 0.89 | SLC6A9 (0.47) | USP2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL9538238 | 0.86 | MEN1 (0.49) | ALDH1A1HTTTDP1MEN1KMT2A | |
| SCHEMBL8565529 | 0.85 | GRIN2B (0.38) | KDM4EALDH1A1HSD17B10MKNK1HTT | |
| SCHEMBL9536425 | 0.85 | KDM4E (0.43) | USP2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL9537470 | 0.84 | KDM4E (0.50) | USP2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL9535315 | 0.84 | ALDH1A1 (0.47) | USP2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL9537145 | 0.84 | SLC6A9 (0.53) | USP2KDM4EHSD17B10TSHRMKNK1 | |
| SCHEMBL9535187 | 0.83 | ALDH1A1 (0.45) | USP2KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL9536807 | 0.83 | SSTR5 (0.50) | USP2SMN1; SMN2HTTHRH1MEN1 | |
| SCHEMBL9536161 | 0.82 | TSHR (0.42) | USP2KDM4EALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |