Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10554908 | 0.93 | HRH1 (0.53) | HRH1SLC6A9KDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL10547503 | 0.87 | SLC6A9 (0.46) | HRH1SLC6A9KDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL9535787 | 0.87 | KDM4E (0.55) | HRH1SLC6A9KDM4ESMN1; SMN2ENPP2 | |
| SCHEMBL9535785 | 0.84 | SLC6A9 (0.58) | HRH1SLC6A9ENPP2LMNAPOLB | |
| SCHEMBL9383173 | 0.82 | SLC6A9 (0.46) | HRH1SLC6A9KDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL9538036 | 0.82 | CCR3 (0.48) | SLC6A9KDM4ESMN1; SMN2ENPP2LMNA | |
| SCHEMBL9538101 | 0.82 | TP53 (0.47) | HRH1SLC6A9KDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL8212306 | 0.81 | SLC6A9 (0.76) | HRH1SLC6A9KDM4ESMN1; SMN2KCNH2 | |
| SCHEMBL9535970 | 0.81 | SLC6A9 (0.55) | SLC6A9KCNH2ENPP2LMNA | |
| SCHEMBL9537927 | 0.78 | LMNA (0.55) | SLC6A9KDM4ESMN1; SMN2ENPP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |