Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10816141 | 0.91 | ENPP2 (0.46) | TP53ENPP2SLC6A9LMNAKDM4E | |
| SCHEMBL9539209 | 0.87 | LMNA (0.55) | TP53ENPP2KCNH2LMNA | |
| SCHEMBL14173523 | 0.84 | KCNH2 (0.51) | KCNH2HRH1GABRA1GABRA5NPY1R | |
| SCHEMBL13186991 | 0.83 | KCNH2 (0.61) | TP53ENPP2KCNH2LMNANPY1R | |
| SCHEMBL9535787 | 0.83 | KDM4E (0.55) | TP53ENPP2SLC6A9LMNAHRH1 | |
| SCHEMBL9535843 | 0.82 | KCNH2 (0.54) | TP53ENPP2KCNH2LMNA | |
| SCHEMBL9535735 | 0.82 | TP53 (0.51) | TP53ENPP2KCNH2SLC6A9LMNA | |
| SCHEMBL9537696 | 0.82 | HRH1 (0.60) | ENPP2KCNH2SLC6A9LMNAHRH1 | |
| SCHEMBL9540161 | 0.81 | SLC6A9 (0.59) | TP53ENPP2KCNH2SLC6A9LMNA | |
| Hydrochloric Acid SCHEMBL9537452 | 0.81 | TP53 (0.50) | TP53ENPP2KCNH2SLC6A9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |