Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538238 | 0.85 | MEN1 (0.49) | GRIN2BLMNAPRMT6CARM1GRM2 | |
| SCHEMBL9536325 | 0.82 | KDM4E (0.48) | OPRL1OGFRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9536807 | 0.80 | SSTR5 (0.50) | OPRM1OPRD1OPRK1LMNACHRM2 | |
| SCHEMBL9537145 | 0.79 | SLC6A9 (0.53) | GRIN2BMKNK1TSHR | |
| SCHEMBL9536155 | 0.79 | USP2 (0.42) | GRIN2BMKNK1TSHR | |
| SCHEMBL9537056 | 0.79 | CCR3 (0.56) | GRIN2BL3MBTL1DRD2DRD3HRH3 | |
| SCHEMBL9539219 | 0.78 | HRH1 (0.42) | GRIN2BMKNK1OPRL1OPRM1LMNA | |
| SCHEMBL8565529 | 0.77 | GRIN2B (0.38) | GRIN2BMKNK1LMNADRD2DRD3 | |
| SCHEMBL9537264 | 0.74 | GBA1 (0.46) | LMNAL3MBTL1CHRM2CHRM4CHRM5 | |
| Water SCHEMBL1151596 | 0.72 | KCNH2 (0.52) | MKNK1OPRM1OPRD1OPRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |