⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536831 | 0.88 | ACHE (0.30) | — | |
| SCHEMBL29937282 | 0.72 | CDC25B (0.38) | — | |
| SCHEMBL2671182 | 0.71 | ITGB2 (0.33) | — | |
| SCHEMBL19644130 | 0.68 | — | — | |
| SCHEMBL2357177 | 0.67 | TSHR (0.30) | — | |
| SCHEMBL29618376 | 0.67 | LMNA (0.37) | — | |
| SCHEMBL31712972 | 0.67 | — | — | |
| SCHEMBL9766381 | 0.67 | DYRK1A (0.38) | — | |
| SCHEMBL2448222 | 0.67 | PDK1 (0.31) | — | |
| SCHEMBL13459980 | 0.67 | MAPT (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117820328-A | Synthesis method of 2, 4-dichloro-6, 7-dihydrofuro [3,2-d ] pyrimidine | 苏州楚凯药业有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117820328-A | Synthesis method of 2, 4-dichloro-6, 7-dihydrofuro [3,2-d ] pyrimidine | 苏州楚凯药业有限公司 | 2024-04-05 | — | — | CN | disclosed |
| US-20230373972-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-11-23 | — | — | US | disclosed |
| US-20230348467-A1 | Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230295163-A1 | TETRACYCLIC DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| WO-2022227987-A1 | HETEROCYCLIC DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2022-11-03 | — | — | WO | disclosed |
| CN-114286824-A | CD73 inhibitor | 博奥阿迪斯生物科技公司 | 2022-04-05 | — | — | CN | disclosed |
| WO-2021143823-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2021-07-22 | — | — | WO | disclosed |
| US-20200353101-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-11-12 | — | — | US | disclosed |
| US-20190269133-A1 | Herbicidal Pyrimidine Compounds | BASF SE (DE) | 2019-09-05 | — | — | US | disclosed |
| US-20190161451-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2019-05-30 | — | — | US | disclosed |
| EP-3487301-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2019-05-29 | — | — | EP | disclosed |
| WO-2018019767-A1 | HERBICIDAL PYRIDINE COMPOUNDS | BASF SE (DE) | 2018-02-01 | — | — | WO | disclosed |
| WO-2018019554-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2018-02-01 | — | — | WO | disclosed |
| WO-2018019765-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2018-02-01 | — | — | WO | disclosed |
| EP-3275877-A1 | HERBICIDAL PYRIDINE COMPOUNDS | BASF SE (DE) | 2018-01-31 | — | — | EP | disclosed |
| US-20070027156-A1 | Crf antagonists and heterobicyclic compounds | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-01 | — | — | US | disclosed |
| US-20070027156-A1 | Crf antagonists and heterobicyclic compounds | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-01 | — | — | US | disclosed |
| EP-0337944-B1 | UREAS | CIBA-GEIGY AG (CH) | 1993-07-28 | — | — | EP | disclosed |
| EP-0337944-A1 | Ureas | CIBA-GEIGY AG (CH) | 1989-10-18 | — | — | EP | disclosed |