Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.66 |
| ▸ | MMP9 | P14780 | 11/20 | 0.66 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.66 |
| ▸ | MMP1 | P03956 | 2/20 | 0.60 |
| ▸ | MMP3 | P08254 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.60 |
| ▸ | MMP7 | P09237 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468716 | 0.88 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL5189189 | 0.88 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL7460419 | 0.88 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL8914953 | 0.87 | MMP2 (0.63) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL9540905 | 0.83 | ADAMTS4 (0.64) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL32691761 | 0.80 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL6545297 | 0.80 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL1920507 | 0.80 | MMP2 (1.00) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL14218257 | 0.80 | MMP2 (0.87) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL4188026 | 0.79 | MMP2 (0.85) | MMP2MMP9ADAMTS4MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |