Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.64 |
| ▸ | MMP2 | P08253 | 9/20 | 0.52 |
| ▸ | MMP13 | P45452 | 8/20 | 0.52 |
| ▸ | MMP1 | P03956 | 7/20 | 0.52 |
| ▸ | MMP9 | P14780 | 7/20 | 0.52 |
| ▸ | MMP3 | P08254 | 6/20 | 0.52 |
| ▸ | MMP7 | P09237 | 4/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914019 | 0.86 | ADAMTS4 (0.61) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL7468791 | 0.83 | ADAMTS4 (0.69) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL7468779 | 0.83 | ADAMTS4 (0.69) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL6806364 | 0.83 | ADAMTS4 (0.69) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL9539647 | 0.83 | MMP2 (0.66) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL4651862 | 0.79 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL1751961 | 0.79 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL8913990 | 0.77 | ADAMTS4 (0.64) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL702794 | 0.76 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL702793 | 0.76 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |