SCHEMBL9540776

SCHEMBL9540776

CCc1ccc(-c2ccc(C3CCC(/C=C/Cl)CC3)cc2)cc1F.Cc1ccc(-c2ccc(C3CCC(/C=C/Cl)CC3)cc2)cc1F

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.36
PLAT P00750 1/20 0.32
ERN1 O75460 1/20 0.31
HDAC2 Q92769 1/20 0.30
TNKS O95271 1/20 0.30
PARP1 P09874 1/20 0.30
KCNH2 Q12809 1/20 0.30
TNKS2 Q9H2K2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8962629 0.94 HDAC2 (0.33) HDAC2
SCHEMBL8962633 0.94 HDAC2 (0.33) HDAC2
SCHEMBL8962838 0.91 SLC6A3 (0.39) SLC6A3PLATERN1HDAC2TNKS
SCHEMBL8962846 0.91 SLC6A3 (0.39) SLC6A3PLATERN1HDAC2TNKS
SCHEMBL8963174 0.85 FFAR4 (0.31)
SCHEMBL8963181 0.85 FFAR4 (0.31)
SCHEMBL8962789 0.82 NAAA (0.34) HDAC2
SCHEMBL8962781 0.82 NAAA (0.34) HDAC2
SCHEMBL8962761 0.81 PANK3 (0.35) HDAC2
SCHEMBL9450894 0.81 SLC6A2 (0.32) SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993007234-A1 HALOVINYL-DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1993-04-15 WO disclosed