Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.69 |
| ▸ | MMP2 | P08253 | 7/20 | 0.66 |
| ▸ | MMP13 | P45452 | 7/20 | 0.66 |
| ▸ | MMP1 | P03956 | 6/20 | 0.66 |
| ▸ | MMP9 | P14780 | 6/20 | 0.66 |
| ▸ | MMP3 | P08254 | 6/20 | 0.66 |
| ▸ | MMP7 | P09237 | 5/20 | 0.66 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.60 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468779 | 1.00 | ADAMTS4 (0.69) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL7468791 | 1.00 | ADAMTS4 (0.69) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL4975578 | 0.84 | ADAMTS4 (0.71) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL698908 | 0.84 | ADAMTS4 (0.71) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL698907 | 0.84 | ADAMTS4 (0.71) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL790069 | 0.84 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL702793 | 0.84 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL702794 | 0.84 | ADAMTS4 (0.81) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL2161562 | 0.83 | MMP2 (0.91) | ADAMTS4MMP2MMP13MMP1MMP9 | |
| SCHEMBL3842066 | 0.83 | MMP2 (0.91) | ADAMTS4MMP2MMP13MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977745-B1 | THIOARYL SULFONAMIDE HYDROXAMIC ACID COMPOUNDS | PHARMACIA CORP (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20040034071-A1 | Thioaryl sulfonamide hydroxamic acid compounds | PHARMACIA CORPORATION | 2004-02-19 | — | — | US | disclosed |
| US-6087359-A | A MATRIX METALLOPROTEASE ENZYME INHIBITOR | PHARMACIA CORPORATION | 2000-07-11 | — | — | US | disclosed |
| EP-0977745-A1 | THIOARYL SULFONAMIDE HYDROXAMIC ACID COMPOUNDS | MONSANTO COMPANY (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998039313-A1 | THIOARYL SULFONAMIDE HYDROXAMIC ACID COMPOUNDS | MONSANTO COMPANY (US) | 1998-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034071-A1 | Thioaryl sulfonamide hydroxamic acid compounds | MMP10, MMP1, MMP3 | ADAMTS4 21/4885MMP2 4/4885MMP13 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.