Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8334055 | 0.86 | LMNA (0.59) | MEN1LMNAKMT2ATDP1ALDH1A1 | |
| Tromethamine SCHEMBL7567125 | 0.85 | LMNA (0.67) | MEN1LMNAKMT2ATDP1ALDH1A1 | |
| Deanol SCHEMBL3422544 | 0.83 | TDP1 (0.40) | MEN1LMNAKMT2ATDP1ALDH1A1 | |
| SCHEMBL1252882 | 0.81 | TDP1 (0.38) | MEN1LMNAKMT2ATDP1ALDH1A1 | |
| Tromethamine SCHEMBL9363390 | 0.80 | MEN1 (0.59) | MEN1LMNAKMT2ATDP1TSHR | |
| Tert-Butylamine SCHEMBL11873692 | 0.79 | MAPK1 (0.39) | LMNATDP1ALDH1A1TSHRCETP | |
| Tromethamine SCHEMBL2263148 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2A | |
| SCHEMBL9387 | 0.78 | — | — | |
| SCHEMBL362926 | 0.78 | — | — | |
| SCHEMBL5036885 | 0.78 | ALDH1A1 (0.50) | LMNATDP1ALDH1A1TSHRCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273890-B1 | A LIQUID DOSAGE FORM FOR ORAL ADMINISTRATION OF A PHARMACEUTICALLY ACTIVE SUBSTANCE | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1993-03-31 | — | — | EP | disclosed |
| US-5085868-A | Microencapsulated with wax coatings in nonaqueous oil; masking unpleasant taste, sustained release, stability | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1992-02-04 | — | — | US | disclosed |
| US-4994260-A | Controlled release of encapsulated substance; polyalcohols and sugars as release agents | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1991-02-19 | — | — | US | disclosed |
| EP-0101418-B1 | PHARMACEUTICAL MIXTURE | Astra Läkemedel Aktiebolag (SE) | 1990-12-27 | — | — | EP | disclosed |
| EP-0273890-A1 | A liquid dosage form for oral administration of a pharmaceutically active substance | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1988-07-06 | — | — | EP | disclosed |
| US-4644001-A | BRONCHODILATOR, CARDIOTONIC AGENTS | AKTIEBOLAGET DRACO (SE) | 1987-02-17 | — | — | US | disclosed |
| US-4548818-A | Composition and methods for the treatment of chronic obstructive airway disease and cardiac disease using 3-alkylxanthines | AKTEBOLAGET DRACO, A COMPANY OF SWEDEN (SE) | 1985-10-22 | — | — | US | disclosed |
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |
| EP-0038784-B1 | 3,8-DIALKYLXANTHINES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Aktiebolaget DRACO (SE) | 1984-10-31 | — | — | EP | disclosed |
| EP-0101418-A2 | Pharmaceutical mixture | Astra Läkemedel Aktiebolag (SE) | 1984-02-22 | — | — | EP | disclosed |