Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL975 | 0.95 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.95 | — | — | |
| Tromethamine SCHEMBL17484 | 0.95 | MEN1 (1.00) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL9298764 | 0.91 | — | — | |
| Tromethamine SCHEMBL11847711 | 0.91 | — | — | |
| Tromethamine SCHEMBL2313359 | 0.91 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL2035496 | 0.91 | — | — | |
| Tromethamine SCHEMBL7091147 | 0.91 | — | — | |
| Tromethamine SCHEMBL7126002 | 0.91 | — | — | |
| Tromethamine SCHEMBL6063594 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4866140-A | OIL, FUEL ADDITIVES | EXXON CHEMICAL PATENTS INC. (US) | 1989-09-12 | — | — | US | claimed |
| WO-2019177056-A1 | MODIFIED PROTEIN, DRUG, PROPHYLACTIC OR THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE, AND METHOD FOR PRODUCING MODIFIED PROTEIN | 国立大学法人北海道大学 | 2019-09-19 | — | — | WO | disclosed |
| WO-2019177053-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR SYSTEMIC LUPUS ERYTHEMATOSUS OR DISEASES CAUSED BY SYSTEMIC LUPUS ERYTHEMATOSUS, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CONNECTIVE TISSUE DISEASES | 国立大学法人北海道大学 | 2019-09-19 | — | — | WO | disclosed |
| US-9492989-B2 | Composition and method for manufacture of a fibrous polyurethane composite product | HAUPT ROBERT A (US) | 2016-11-15 | — | — | US | disclosed |
| US-20110189490-A1 | COMPOSITION AND METHOD FOR MANUFACTURE OF A FIBROUS POLYURETHANE COMPOSITE PRODUCT | HAUPT ROBERT A | 2011-08-04 | — | — | US | disclosed |