Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | BID | P55957 | 6/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.34 |
| ▸ | BAK1 | Q16611 | 5/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | F7 | P08709 | 2/20 | 0.33 |
| ▸ | F3 | P13726 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954875 | 1.00 | CYP3A4 (0.37) | CYP3A4CYP2D6CYP2C9CNR2BID | |
| SCHEMBL954246 | 0.90 | GABRA1 (0.39) | CNR2GABRA1GABRB2 | |
| SCHEMBL954245 | 0.90 | GABRA1 (0.39) | CNR2GABRA1GABRB2 | |
| SCHEMBL958998 | 0.84 | GABRA1 (0.43) | CNR2ALOX15GABRA1GABRB2 | |
| SCHEMBL959000 | 0.84 | GABRA1 (0.43) | CNR2ALOX15GABRA1GABRB2 | |
| SCHEMBL4610942 | 0.80 | CNR2 (0.36) | CYP3A4CYP2D6CYP2C9CNR2BID | |
| SCHEMBL953193 | 0.79 | GABRA1 (0.34) | CYP3A4GABRA1GABRB2 | |
| SCHEMBL953195 | 0.79 | GABRA1 (0.34) | CYP3A4GABRA1GABRB2 | |
| SCHEMBL952745 | 0.77 | AMY1A (0.39) | KDM4EMAPTALOX5PTGS2 | |
| SCHEMBL952744 | 0.77 | AMY1A (0.39) | KDM4EMAPTALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875645-B2 | 2-(2-cyclopropyl-benzyl)-4,5-dihydro-1H-imidazole; depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders | HOFFMAN-LA ROCHE INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-20070197621-A1 | Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197621-A1 | Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives | GPR119, PER2, MTNR1B | CYP3A4 118/4885CYP2D6 338/4885CYP2C9 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.