Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11724111 | 0.80 | ALDH1A1 (0.46) | MAPTALOX15ALDH1A1TDP1KDM4E | |
| SCHEMBL9550798 | 0.80 | CYP2C9 (0.39) | MAPTTDP1KDM4ESMN1; SMN2CYP2D6 | |
| SCHEMBL9168126 | 0.77 | ALOX15 (0.50) | HPNMAPTALOX15SIRT5ALDH1A1 | |
| SCHEMBL10514524 | 0.77 | CYP2D6 (0.32) | CYP2D6CYP2C9 | |
| SCHEMBL9492905 | 0.75 | ALOX15 (0.47) | HPNMAPTALOX15SIRT5ALDH1A1 | |
| SCHEMBL646924 | 0.74 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5ALDH1A1 | |
| SCHEMBL9550788 | 0.74 | NPC1 (0.36) | ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL9621562 | 0.73 | ALOX15 (0.46) | HPNMAPTALOX15SIRT5ALDH1A1 | |
| SCHEMBL8702044 | 0.71 | ALOX15 (0.59) | HPNMAPTALOX15SIRT5ALDH1A1 | |
| SCHEMBL9701573 | 0.71 | HPN (0.44) | HPNMAPTALOX15SIRT5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0218782-B1 | LIPOXYGENASE-INHIBITING COMPOSITION AND HYDROXYPHENYLTHIOALKYLCARBONYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |