Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SORD | Q00796 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678393 | 0.79 | L3MBTL1 (0.50) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL2074811 | 0.77 | SORD (0.51) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL2320496 | 0.74 | SORD (0.51) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL31014265 | 0.74 | SORD (0.51) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL18228513 | 0.74 | SORD (0.51) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL15887427 | 0.73 | SORD (0.51) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL2074813 | 0.73 | LMNA (0.54) | LMNAL3MBTL1SORDKDM4ESLC6A7 | |
| SCHEMBL27723124 | 0.72 | SLC6A7 (0.59) | LMNAL3MBTL1SORDKDM4ESLC6A7 | |
| SCHEMBL9558287 | 0.72 | SORD (0.51) | LMNAL3MBTL1SORDKDM4EDRD4 | |
| SCHEMBL2320514 | 0.72 | SORD (0.50) | LMNAL3MBTL1SORDKDM4EDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215967-A | AMINOACID DERIVATIVES INHIBITING RENIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0371390-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1990-06-06 | — | — | EP | disclosed |