Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9557988 | 0.99 | PLA2G4B (0.57) | PLA2G4BCYSLTR1GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9506788 | 0.88 | PLA2G4B (0.60) | PLA2G4BTP53TSHRNR1H4PKM | |
| SCHEMBL10412747 | 0.86 | CYSLTR1 (0.57) | PLA2G4BCYSLTR1GRIN2DGRIN2AGRIN2B | |
| SCHEMBL10412008 | 0.85 | CYSLTR1 (0.54) | PLA2G4BCYSLTR1GRIN2DGRIN2AGRIN2B | |
| SCHEMBL9507024 | 0.85 | PKM (0.53) | PLA2G4BTP53TSHRPKMRARB | |
| SCHEMBL9558448 | 0.84 | PPARA (0.52) | CYSLTR1FFAR1 | |
| SCHEMBL9557961 | 0.83 | PPARA (0.54) | CYSLTR1 | |
| SCHEMBL9558408 | 0.82 | PLA2G4B (0.60) | PLA2G4BCYSLTR1NR1H4PKMFFAR1 | |
| SCHEMBL9559075 | 0.81 | LTB4R (0.48) | GRIN2DGRIN2AGRIN2BGRIN2CHTT | |
| SCHEMBL1123048 | 0.79 | PKM (0.61) | PLA2G4BCYSLTR1NR1H4PKMFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384350-B1 | DIHYDROXY NAPHTHALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-28 | — | — | EP | disclosed |
| EP-0384350-A1 | Dihydroxy naphthalene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |
| US-4937371-A | INHIBITING LIPOXYGENASE | HOFFMANN-LA ROCHE INC. (US) | 1990-06-26 | — | — | US | disclosed |