Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9226202 | 0.95 | EPHX2 (0.51) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9230859 | 0.90 | HTR1A (0.47) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9223178 | 0.87 | TSHR (0.54) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9227522 | 0.85 | TSHR (0.53) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9227703 | 0.85 | MAPT (0.49) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9590562 | 0.84 | ALDH1A1 (0.63) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9227826 | 0.82 | TSHR (0.51) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9226276 | 0.81 | ALDH1A1 (0.52) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9224851 | 0.80 | ALDH1A1 (0.50) | TSHRKMT2AGAAMAPTEPHX2 | |
| SCHEMBL9230400 | 0.80 | DRD2 (0.48) | TSHRKMT2AMAPTEPHX2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |