Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939638 | 0.76 | MEN1 (0.41) | ALDH1A1LMNAMAPTCYSLTR2CYSLTR1 | |
| SCHEMBL586358 | 0.74 | CYSLTR2 (0.48) | CYP3A4LMNAMAPTCYSLTR2CYSLTR1 | |
| SCHEMBL7093157 | 0.73 | ALDH1A1 (0.70) | ALDH1A1HPGDCYP3A4ALOX15USP2 | |
| SCHEMBL9560073 | 0.72 | CYSLTR2 (0.73) | CYSLTR2CYSLTR1 | |
| SCHEMBL7094868 | 0.71 | ALDH1A1 (0.67) | ALDH1A1HPGDCYP3A4ALOX15USP2 | |
| SCHEMBL9560129 | 0.71 | ALDH1A1 (0.47) | ALDH1A1HPGDCYP3A4ALOX15USP2 | |
| SCHEMBL10510771 | 0.70 | ALDH1A1 (0.44) | ALDH1A1HPGDCYP3A4ALOX15USP2 | |
| SCHEMBL27985442 | 0.69 | MPO (0.46) | ALDH1A1HPGDCYP3A4ALOX15USP2 | |
| SCHEMBL28759082 | 0.69 | ALDH1A1 (0.51) | ALDH1A1HPGDCYP3A4ALOX15USP2 | |
| SCHEMBL9560079 | 0.69 | ALDH1A1 (0.40) | ALDH1A1HPGDCYP3A4ALOX15USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358240-B1 | INTERMEDIATES FOR THE PREPARATION OF LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-09 | — | — | EP | disclosed |
| US-5034537-A | Alpha-methyl-4-halobenzenemethanamine salts of acids for cardiovascular disorders, respiratory system disorders and antiallergens | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| US-4939279-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0202759-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-20 | — | — | EP | disclosed |
| EP-0358240-A2 | Intermediates for the preparation of leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4874792-A | RESPIRATORY SYSTEM DISORDERS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4820719-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIISCHEMIC AND HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0202759-A2 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1986-11-26 | — | — | EP | disclosed |