Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586358 | 0.84 | CYSLTR2 (0.48) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL30307843 | 0.81 | MEN1 (0.46) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL6444765 | 0.81 | MEN1 (0.46) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL23748253 | 0.76 | MEN1 (0.39) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL9560130 | 0.76 | ALDH1A1 (0.43) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL6899385 | 0.76 | MEN1 (0.49) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL8183495 | 0.76 | MEN1 (0.44) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL6055110 | 0.76 | GABRA1 (0.45) | LMNAALDH1A1SLC6A2CYSLTR2CYSLTR1 | |
| SCHEMBL27560047 | 0.76 | MEN1 (0.44) | MEN1MAPTCYP2C9KMT2ALMNA | |
| SCHEMBL10900322 | 0.75 | MEN1 (0.38) | MEN1MAPTCYP2C9KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |