SCHEMBL9561663

SCHEMBL9561663

CCOc1c(F)cc([C@](Cl)(COCc2cccc(Oc3ccc(Cl)cc3)c2)C(F)(F)F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
CETP P11597 4/20 0.34
LMNA P02545 2/20 0.34
PPARG P37231 1/20 0.34
PPARA Q07869 1/20 0.34
MAPK1 P28482 1/20 0.33
FFAR1 O14842 4/20 0.33
FFAR4 Q5NUL3 2/20 0.33
GAA P10253 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
MAOB P27338 1/20 0.32
RORC P51449 1/20 0.32
MGLL Q99685 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9561658 1.00 ALDH1A1 (0.39) ALDH1A1CETPLMNAPPARGPPARA
SCHEMBL9561537 0.93 CETP (0.39) ALDH1A1CETPLMNAMAPK1FFAR1
SCHEMBL9561530 0.93 CETP (0.39) ALDH1A1CETPLMNAMAPK1FFAR1
SCHEMBL9560874 0.91 ALDH1A1 (0.38) ALDH1A1CETPLMNAPPARGPPARA
SCHEMBL9560848 0.90 ALDH1A1 (0.42) ALDH1A1CETPLMNAPPARGPPARA
SCHEMBL9560888 0.88 ALDH1A1 (0.39) ALDH1A1CETPLMNAPPARGPPARA
SCHEMBL9560883 0.88 ALDH1A1 (0.39) ALDH1A1CETPLMNAPPARGPPARA
SCHEMBL9560713 0.84 LTA4H (0.46) ALDH1A1CETPLMNAMAPK1FFAR1
SCHEMBL9637902 0.83 L3MBTL1 (0.33) LMNAPPARGFFAR1RORC
SCHEMBL9560723 0.83 FFAR1 (0.39) ALDH1A1CETPPPARGPPARAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
EP-0276558-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-08 EP disclosed