SCHEMBL9560874

SCHEMBL9560874

CCOc1ccc(C(Cl)(COCc2cccc(Oc3ccc(Cl)cc3)c2)C(F)(F)F)cc1F

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
FFAR1 O14842 5/20 0.37
PPARD Q03181 5/20 0.37
MRGPRX4 Q96LA9 2/20 0.35
LMNA P02545 2/20 0.33
ATM Q13315 2/20 0.33
MAPT P10636 2/20 0.33
BRD4 O60885 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PPARG P37231 2/20 0.33
PPARA Q07869 2/20 0.33
CETP P11597 2/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9560723 0.93 FFAR1 (0.39) ALDH1A1FFAR1PPARDBRD4L3MBTL1
SCHEMBL9561663 0.91 ALDH1A1 (0.39) ALDH1A1FFAR1LMNAPPARGPPARA
SCHEMBL9561658 0.91 ALDH1A1 (0.39) ALDH1A1FFAR1LMNAPPARGPPARA
SCHEMBL9560848 0.88 ALDH1A1 (0.42) ALDH1A1FFAR1MRGPRX4LMNAATM
SCHEMBL9560797 0.88 FFAR1 (0.38) ALDH1A1FFAR1PPARDMRGPRX4LMNA
SCHEMBL9561537 0.84 CETP (0.39) ALDH1A1FFAR1LMNAATML3MBTL1
SCHEMBL9561530 0.84 CETP (0.39) ALDH1A1FFAR1LMNAATML3MBTL1
SCHEMBL9560713 0.82 LTA4H (0.46) ALDH1A1FFAR1MRGPRX4LMNAATM
SCHEMBL9560778 0.81 ALDH1A1 (0.39) ALDH1A1FFAR1LMNAPPARGPPARA
SCHEMBL9560888 0.80 ALDH1A1 (0.39) ALDH1A1FFAR1LMNAPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5225607-A Multistage etherification or dehydrohalogenation and reductive dechlorination IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-06 US disclosed
US-5196610-A INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-03-23 US disclosed
EP-0211561-B1 INSECTICIDAL ETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-11 EP disclosed
EP-0211561-A1 Insecticidal ethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-02-25 EP disclosed