Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL30592706 | 1.00 | TSHR (0.79) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Maleic Acid SCHEMBL956148 | 1.00 | TSHR (0.79) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL29132468 | 0.96 | TSHR (0.73) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Acrylic Acid SCHEMBL27491143 | 0.91 | TSHR (0.86) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Acrylic Acid SCHEMBL1665306 | 0.91 | TSHR (0.86) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Acrylic Acid SCHEMBL28805889 | 0.91 | TSHR (0.86) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Hydrogen Peroxide SCHEMBL9125524 | 0.91 | TSHR (0.95) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL29185571 | 0.89 | TSHR (0.63) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Monomethyl Fumarate SCHEMBL28099233 | 0.89 | TSHR (0.63) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| Maleic Acid SCHEMBL3892059 | 0.89 | TSHR (0.67) | TSHRALDH1A1TP53HIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215194-A1 | ENHANCED REMOVABILITY OF NAIL COATINGS USING ACIDIC COPOLYMERS FOR TRIGGERED REMOVAL WITH AQUEOUS BASED REMOVER | ARKEMA FRANCE (FR) | 2025-10-16 | — | — | WO | claimed |
| WO-2025215194-A1 | ENHANCED REMOVABILITY OF NAIL COATINGS USING ACIDIC COPOLYMERS FOR TRIGGERED REMOVAL WITH AQUEOUS BASED REMOVER | ARKEMA FRANCE (FR) | 2025-10-16 | — | — | WO | disclosed |
| WO-2025215193-A1 | ACIDIC OLIGOMERS USED IN DEINKING PROCESS | ARKEMA FRANCE (FR) | 2025-10-16 | — | — | WO | disclosed |
| CN-110546134-B | Oxime ester compound and photopolymerization initiator containing the same | 株式会社艾迪科 | 2024-12-20 | — | — | CN | disclosed |
| CN-106470971-B | Novel polymerization initiator and radical polymerizable composition containing the same | 株式会社艾迪科 | 2020-03-03 | — | — | CN | disclosed |
| CN-110546134-A | Oxime ester compound and photopolymerization initiator containing the same | ADEKA CORP | 2019-12-06 | — | — | CN | disclosed |
| EP-2669339-B1 | NOVEL COMPOUND, DYE AND COLORED PHOTOSENSITIVE COMPOSITION | ADEKA CORP (JP) | 2017-01-18 | — | — | EP | disclosed |
| US-9334270-B2 | Polymerizable (photosensitive or reactive) cyano-containing compound, a dye, and colored photosensitive composition | ADEKA CORPORATION (JP) | 2016-05-10 | — | — | US | disclosed |
| US-9239408-B2 | Colored photosensitive composition | ADEKA CORPORATION (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9029434-B2 | Colored photosensitive composition | ADEKA CORPORATION (JP) | 2015-05-12 | — | — | US | disclosed |
| US-7875407-B2 | epoxy resins; photopolymerization initiators; for liquid crystal displays, plasma displays, electroluminescence panels, video cameras | TOPPAN PRINTING CO., LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| US-20100129753-A1 | ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND BETA-DIKETONE COMPOUND | ADEKA CORPORATION (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-2175320-A1 | ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND -DIKETONE COMPOUND | Adeka Corporation (JP) | 2010-04-14 | — | — | EP | disclosed |
| US-20090202750-A1 | COLORED ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND COLOR FILTER USING THE SAME | TOPPAN PRINTING CO., LTD. (JP) | 2009-08-13 | — | — | US | disclosed |
| EP-0872529-B2 | BINDER FOR BUILDING STRUCTURES | ASAHI CHEMICAL IND (JP) | 2008-07-09 | — | — | EP | disclosed |
| EP-0872529-B1 | BINDER FOR BUILDING STRUCTURES | ASAHI CHEMICAL IND (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6015845-A | Binder for building structure | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2000-01-18 | — | — | US | disclosed |
| EP-0872529-A1 | BINDER FOR BUILDING STRUCTURES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1998-10-21 | — | — | EP | disclosed |
| US-4914172-A | BIODEGRADABLE SEED COATINGS | BASF AKTIENGESELLSCHAFT (DE) | 1990-04-03 | — | — | US | disclosed |
| US-3940349-A | Compositions and process for making rigid plastic foams of modified vinyl ester resins and silicone compounds | THE DOW CHEMICAL COMPANY (US) | 1976-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129753-A1 | ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND BETA-DIKETONE COMPOUND | RPS14, ACAD11, OR10J3 | TSHR 3404/4885ALDH1A1 1770/4885TP53 4062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.