SCHEMBL9564533

SCHEMBL9564533

O=c1[nH]c2cc(Cl)c(Cl)cc2cc1NS(=O)(=O)C(F)(F)F

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 3/20 0.58
GRIA2 P42262 3/20 0.58
GRIA3 P42263 3/20 0.58
GRIA4 P48058 3/20 0.58
CA2 P00918 7/20 0.43
CA1 P00915 3/20 0.43
GRIN2D O15399 2/20 0.41
GRIN3B O60391 2/20 0.41
GRIN1 Q05586 2/20 0.41
GRIN2A Q12879 2/20 0.41
GRIN2B Q13224 2/20 0.41
GRIN2C Q14957 2/20 0.41
GRIN3A Q8TCU5 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
CYP1A2 P05177 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564526 0.83 GRIA1 (0.66) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564549 0.79 GRIA1 (0.54) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564548 0.79 GRIA1 (0.70) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564541 0.78 GRIA1 (0.63) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564531 0.78 GRIA1 (0.66) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564555 0.78 GRIA1 (0.47) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564524 0.78 GRIA1 (0.47) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564528 0.78 GRIA1 (0.56) GRIA1GRIA2GRIA3GRIA4CA2
SCHEMBL9564538 0.74 GRIA1 (0.58) GRIA1GRIA2GRIA3GRIA4PTGS1
SCHEMBL9564532 0.74 GRIA1 (1.00) GRIA1GRIA2GRIA3GRIA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0542609-A1 3-sulfonylamino-2-(1H)-quinolinones and 7-aza derivatives as excitatory amino acids antagonists ADIR ET COMPAGNIE (FR) 1993-05-19 EP disclosed