Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.37 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564800 | 1.00 | GAA (0.41) | GAAHSD17B10CASP1CASP7MAP4K4 | |
| SCHEMBL10875077 | 0.69 | MAPK14 (0.39) | GAAHSD17B10MAP4K4MAPK14SMN1; SMN2 | |
| SCHEMBL9564937 | 0.68 | HSD17B10 (0.47) | GAAHSD17B10CASP1CASP7OPRD1 | |
| SCHEMBL9564786 | 0.68 | ALDH1A1 (0.47) | GAAHSD17B10CASP1CASP7MAP4K4 | |
| SCHEMBL9564912 | 0.66 | HSD17B10 (0.46) | GAAHSD17B10CASP1CASP7OPRD1 | |
| SCHEMBL9564876 | 0.65 | HSD17B10 (0.46) | GAAHSD17B10CASP1CASP7OPRD1 | |
| Bromide SCHEMBL11338873 | 0.63 | ALDH1A1 (0.63) | GAAHSD17B10CASP1CASP7KDM4E | |
| SCHEMBL9564842 | 0.63 | MAP4K4 (0.45) | GAAHSD17B10MAP4K4SMN1; SMN2KDM4E | |
| SCHEMBL9564902 | 0.63 | USP2 (0.51) | GAAHSD17B10CASP1CASP7MAP4K4 | |
| SCHEMBL9564844 | 0.62 | CYP1A2 (0.50) | GAAHSD17B10CASP1CASP7MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258380-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-02 | — | — | US | disclosed |
| US-5041448-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |