SCHEMBL9564902

SCHEMBL9564902

CCOC(=O)N1CCC(Nc2nc3cncnc3n2Cc2ccc(F)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 5/20 0.51
CYP1A2 P05177 5/20 0.51
CYP3A4 P08684 5/20 0.51
CYP2C9 P11712 4/20 0.51
CYP2C19 P33261 4/20 0.51
ALDH1A1 P00352 8/20 0.50
GAA P10253 4/20 0.50
LMNA P02545 3/20 0.50
KDM4E B2RXH2 3/20 0.47
MAPT P10636 2/20 0.47
HSD17B10 Q99714 3/20 0.47
HPGD P15428 3/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
MAPK14 Q16539 1/20 0.46
MAPK1 P28482 3/20 0.46
HIF1A Q16665 1/20 0.46
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
NOS2 P35228 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9629419 0.97 USP2 (0.48) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9564864 0.91 ALDH1A1 (0.51) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9565029 0.91 ALDH1A1 (0.51) USP2CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL11278989 0.87 LMNA (0.55) USP2CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL9564841 0.86 USP2 (0.49) USP2CYP1A2CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL9699826 0.84 GAA (0.55) USP2CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL9602879 0.84 NOS2 (0.56) ALDH1A1KDM4EMAPTHSD17B10HPGD
SCHEMBL9564774 0.84 ALDH1A1 (0.44) ALDH1A1LMNAKDM4EMAPTHSD17B10
SCHEMBL10428791 0.83 LMNA (0.57) USP2CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL9564803 0.83 NOS2 (0.46) ALDH1A1LMNAKDM4EMAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5258380-A Antiallergens, antihistamines JANSSEN PHARMACEUTICA N.V. (BE) 1993-11-02 US disclosed
EP-0206415-B1 (4-PIPERIDINYLMETHYL AND -HETERO)PURINES JANSSEN PHARMACEUTICA N.V. (BE) 1993-01-27 EP disclosed
US-5041448-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-08-20 US disclosed
EP-0206415-A2 (4-Piperidinylmethyl and -hetero)purines JANSSEN PHARMACEUTICA N.V. (BE) 1986-12-30 EP disclosed