SCHEMBL9564841

SCHEMBL9564841

CCOC(=O)N1CCC(NCc2nc3cncnc3n2Cc2ccc(F)cc2)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 8/20 0.49
CYP1A2 P05177 8/20 0.49
CYP3A4 P08684 8/20 0.49
CYP2C9 P11712 7/20 0.49
CYP2C19 P33261 6/20 0.49
MAPK1 P28482 5/20 0.44
HIF1A Q16665 2/20 0.44
HSD17B10 Q99714 2/20 0.44
CASP1 P29466 1/20 0.44
CASP7 P55210 1/20 0.44
MAPT P10636 4/20 0.43
TP53 P04637 3/20 0.43
ALDH1A1 P00352 6/20 0.43
TSHR P16473 4/20 0.43
LMNA P02545 4/20 0.43
SMN1; SMN2 Q16637 5/20 0.42
HPGD P15428 3/20 0.42
ALOX15 P16050 1/20 0.42
POLB P06746 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564902 0.86 USP2 (0.51) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9629419 0.84 USP2 (0.48) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9699714 0.83 ALDH1A1 (0.53) USP2CYP1A2CYP3A4CYP2C19MAPK1
SCHEMBL9564844 0.81 CYP1A2 (0.50) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9564864 0.78 ALDH1A1 (0.51) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9565029 0.77 ALDH1A1 (0.51) USP2CYP1A2CYP3A4CYP2C19MAPK1
SCHEMBL9564912 0.74 HSD17B10 (0.46) USP2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL11278989 0.73 LMNA (0.55) USP2CYP1A2CYP3A4CYP2C19MAPT
SCHEMBL9564876 0.73 HSD17B10 (0.46) HSD17B10CASP1CASP7MAPTTP53
Hydrochloric Acid SCHEMBL9699826 0.72 GAA (0.55) USP2CYP1A2CYP3A4CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5258380-A Antiallergens, antihistamines JANSSEN PHARMACEUTICA N.V. (BE) 1993-11-02 US disclosed
EP-0206415-B1 (4-PIPERIDINYLMETHYL AND -HETERO)PURINES JANSSEN PHARMACEUTICA N.V. (BE) 1993-01-27 EP disclosed
US-5041448-A Antiallergens JANSSEN PHARMACEUTICA N.V. (BE) 1991-08-20 US disclosed
EP-0206415-A2 (4-Piperidinylmethyl and -hetero)purines JANSSEN PHARMACEUTICA N.V. (BE) 1986-12-30 EP disclosed