SCHEMBL9567372

SCHEMBL9567372

CCCCc1nc(Cl)c(/C=C/C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AGT P01019 2/20 0.56
AGTR1 P30556 4/20 0.53
AGTR2 P50052 4/20 0.53
GP6 Q9HCN6 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9424366 0.93 AGTR1 (0.56) AGTAGTR1AGTR2GP6
SCHEMBL9424364 0.93 AGTR1 (0.56) AGTAGTR1AGTR2GP6
SCHEMBL894 0.87 GP6 (0.62) AGTAGTR1AGTR2GP6
SCHEMBL9294985 0.86 AGT (0.68) AGTAGTR1AGTR2
SCHEMBL9294992 0.86 AGT (0.68) AGTAGTR1AGTR2
SCHEMBL9563496 0.85 AGT (0.53) AGTAGTR1AGTR2GP6
SCHEMBL498022 0.84 AGTR2 (0.63) AGTAGTR1AGTR2
SCHEMBL9566013 0.83 AGT (0.51) AGTAGTR1AGTR2GP6
SCHEMBL809 0.83 AGT (0.57) AGTAGTR1AGTR2
SCHEMBL9947753 0.83 AGT (0.58) AGTAGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0535463-A1 Imidazolpropen acid derivatives as angiotensin II antagonists BAYER AG (DE) 1993-04-07 EP disclosed