Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 15/20 | 0.47 |
| ▸ | CA1 | P00915 | 14/20 | 0.47 |
| ▸ | CA9 | Q16790 | 13/20 | 0.47 |
| ▸ | CA12 | O43570 | 11/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA6 | P23280 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1864564 | 0.74 | F2RL3 (0.39) | MAPK1MEN1KMT2ACYP2C9 | |
| SCHEMBL4907475 | 0.70 | CA1 (0.55) | CA2CA1CA9CA12CDK2 | |
| SCHEMBL7404316 | 0.70 | VKORC1 (0.44) | CA2CA1CA9CA12MEN1 | |
| SCHEMBL9138970 | 0.68 | CDK2 (0.78) | CA2CA1CA9CA12CDK2 | |
| SCHEMBL9569787 | 0.67 | CA2 (0.50) | CA2CA1CA9CA12CDK2 | |
| SCHEMBL28142355 | 0.67 | MAOA (0.62) | CA2CA1CA9CA12CDK2 | |
| SCHEMBL12278178 | 0.67 | PIM1 (0.34) | MAPK1MEN1KMT2A | |
| SCHEMBL9569792 | 0.66 | LMNA (0.44) | CA2CA1CA9CA12CA4 | |
| SCHEMBL10583631 | 0.65 | CA1 (0.62) | CA2CA1CA9CA12MEN1 | |
| SCHEMBL10914937 | 0.64 | CA2 (0.50) | CA2CA1CA9CA12CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560554-A2 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5169860-A | Benzofuran or benzothiophene arylsulfonylureas | ELI LILLY AND COMPANY (US) | 1992-12-08 | — | — | US | disclosed |