SCHEMBL9570745

SCHEMBL9570745

O=CC(c1ccc(C(F)(F)F)cc1)C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.43
CES1 P23141 2/20 0.43
ACP3 P15309 1/20 0.41
PDE2A O00408 1/20 0.38
CYP1A2 P05177 1/20 0.37
GSK3B P49841 1/20 0.37
PTGS1 P23219 1/20 0.36
HSD11B1 P28845 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36
KIF11 P52732 1/20 0.35
EPHX2 P34913 1/20 0.35
FBP1 P09467 1/20 0.35
CNR2 P34972 1/20 0.35
ORAI1 Q96D31 1/20 0.34
ORAI2 Q96SN7 1/20 0.34
ORAI3 Q9BRQ5 1/20 0.34
TRPV6 Q9H1D0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9570684 0.84 TSHR (0.44) PDE2ACYP1A2ALDH1A1TSHR
SCHEMBL9570588 0.84 PDE2A (0.32) CES2CES1PDE2A
SCHEMBL9570686 0.81 PDE2A (0.30) PDE2A
SCHEMBL9570876 0.81 IDO1 (0.35) CES2CES1ALDH1A1
SCHEMBL9570777 0.79 TSHR (0.40) TSHRCNR2
SCHEMBL9570796 0.79 TYR (0.48) ALDH1A1
SCHEMBL9570654 0.79 CYP2A6 (0.38) ALDH1A1
SCHEMBL9570639 0.79 HTR2A (0.35) CYP1A2
SCHEMBL15333298 0.78 CES2 (0.46) CES2CES1ACP3PDE2ACYP1A2
SCHEMBL1225030 0.78 CYP2D6 (0.39) ACP3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0545891-A2 Aldehyde compounds and derivatives thereof useful as intermediates in the preparation of insectical ether compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-06-09 EP disclosed
US-4840971-A INSECTICIDES, MITICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-06-20 US disclosed
EP-0240978-A2 Ether compounds, process for their preparation, compositions containing the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-10-14 EP disclosed