SCHEMBL9570796

SCHEMBL9570796

CC(C)c1ccc(C(C=O)C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TYR P14679 3/20 0.48
PTPN5 P54829 2/20 0.40
CYP2C9 P11712 3/20 0.37
CYP2D6 P10635 1/20 0.37
HIF1A Q16665 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MAPK1 P28482 1/20 0.36
FKBP1A P62942 1/20 0.35
MGLL Q99685 1/20 0.34
POLB P06746 2/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
PIM1 P11309 1/20 0.33
HTT P42858 1/20 0.32
ALDH1A1 P00352 1/20 0.32
SIRT2 Q8IXJ6 1/20 0.32
SIRT1 Q96EB6 1/20 0.32
SIRT5 Q9NXA8 1/20 0.32
USP5 P45974 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9570654 0.83 CYP2A6 (0.38) TYRGAAHTTALDH1A1
SCHEMBL9570777 0.83 TSHR (0.40) HIF1AMAPK1MGLLLMNAGAA
SCHEMBL9570876 0.81 IDO1 (0.35) LMNAGAAALDH1A1
SCHEMBL9570684 0.80 TSHR (0.44) TYRHIF1ALMNAHTTALDH1A1
SCHEMBL9570578 0.80 ALDH1A3 (0.50) PTPN5MAPK1POLBGAAALDH1A1
SCHEMBL9570639 0.79 HTR2A (0.35)
SCHEMBL9570745 0.79 CES2 (0.43) ALDH1A1
SCHEMBL9570869 0.79 ALDH1A1 (0.44) CYP2D6MAPK1ALDH1A1
SCHEMBL9570843 0.79 TSHR (0.41) CYP2C9MAPK1MGLLPOLBLMNA
SCHEMBL1225030 0.78 CYP2D6 (0.39) CYP2D6MAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0545891-A2 Aldehyde compounds and derivatives thereof useful as intermediates in the preparation of insectical ether compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-06-09 EP disclosed
EP-0240978-A2 Ether compounds, process for their preparation, compositions containing the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-10-14 EP disclosed