SCHEMBL9570684

SCHEMBL9570684

CC(C)(C)c1ccc(C(C=O)C(F)(F)F)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.44
TP53 P04637 1/20 0.44
GRIA4 P48058 3/20 0.37
LMNA P02545 2/20 0.35
TYR P14679 1/20 0.35
PDE2A O00408 1/20 0.35
CYP1A2 P05177 1/20 0.35
NR1H4 Q96RI1 1/20 0.35
AKR1C3 P42330 1/20 0.35
AKR1C2 P52895 1/20 0.35
ALDH1A1 P00352 3/20 0.34
TRPV1 Q8NER1 2/20 0.34
PDK1 Q15118 1/20 0.34
PDK2 Q15119 1/20 0.34
PDK3 Q15120 1/20 0.34
PDK4 Q16654 1/20 0.34
HSD17B10 Q99714 1/20 0.34
EEF2K O00418 1/20 0.34
HDAC1 Q13547 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9570745 0.84 CES2 (0.43) TSHRPDE2ACYP1A2ALDH1A1
SCHEMBL9570588 0.81 PDE2A (0.32) PDE2A
SCHEMBL9570796 0.80 TYR (0.48) LMNATYRALDH1A1HTTHIF1A
SCHEMBL9570654 0.80 CYP2A6 (0.38) TYRAKR1C3AKR1C2ALDH1A1MEN1
SCHEMBL9570686 0.78 PDE2A (0.30) PDE2A
SCHEMBL9570876 0.78 IDO1 (0.35) LMNAALDH1A1HDAC1
SCHEMBL9570777 0.76 TSHR (0.40) TSHRTP53LMNAHSD17B10HIF1A
SCHEMBL9570639 0.76 HTR2A (0.35) CYP1A2
SCHEMBL9570869 0.76 ALDH1A1 (0.44) TSHRCYP1A2ALDH1A1MEN1KMT2A
SCHEMBL9570843 0.76 TSHR (0.41) TSHRTP53LMNACYP1A2AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0545891-A2 Aldehyde compounds and derivatives thereof useful as intermediates in the preparation of insectical ether compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-06-09 EP disclosed
EP-0240978-A2 Ether compounds, process for their preparation, compositions containing the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-10-14 EP disclosed