Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9573321 | 0.81 | EPHX2 (0.50) | ALOX15LMNAMAPTHSD17B10ALDH1A1 | |
| SCHEMBL9572914 | 0.77 | KDM4E (0.50) | LMNAMAPTHSD17B10ALDH1A1HPGD | |
| SCHEMBL9572816 | 0.75 | EPHX2 (0.54) | ALOX15LMNAMAPTALDH1A1HPGD | |
| SCHEMBL7509259 | 0.67 | CNR1 (0.51) | ALOX15TSHRCNR1 | |
| SCHEMBL9572947 | 0.67 | LMNA (0.48) | LMNAMAPTALDH1A1TSHRGAA | |
| SCHEMBL9572935 | 0.67 | F10 (0.40) | LMNATSHRHTTNPSR1 | |
| SCHEMBL16254239 | 0.67 | ALDH1A1 (0.55) | MAPTHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL6649593 | 0.66 | HTT (0.69) | LMNAMAPTALDH1A1HPGDTSHR | |
| SCHEMBL15512501 | 0.65 | OXER1 (0.62) | ALOX15MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL9268276 | 0.65 | OXER1 (0.62) | ALOX15MAPTALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562832-A1 | Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1993-09-29 | — | — | EP | disclosed |