Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100B | P04271 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | GLB1 | P16278 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10974740 | 0.98 | CA12 (0.40) | S100BCA12CA1CA2CA9 | |
| SCHEMBL3782607 | 0.77 | HPGD (0.42) | MEN1NPC1KMT2AMAPTKDM4E | |
| SCHEMBL11215407 | 0.77 | MAPT (0.44) | CA12CA2CA9MEN1NPC1 | |
| SCHEMBL9421173 | 0.77 | PTGS1 (0.37) | CA1CA2MEN1KMT2AMAPT | |
| SCHEMBL1741629 | 0.76 | ALDH1A1 (0.39) | MEN1NPC1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL10815621 | 0.76 | MAPT (0.42) | CA12CA2CA9MEN1NPC1 | |
| Bromide SCHEMBL11354612 | 0.76 | BACE1 (0.35) | — | |
| Bromide SCHEMBL11356265 | 0.74 | SELL (0.31) | — | |
| SCHEMBL10969178 | 0.72 | ALDH1A1 (0.38) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL10967741 | 0.72 | ALOX15 (0.41) | MEN1KMT2AMAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5180721-A | Imidazoline substituted naphthalene compounds for treatment of glaucoma | ALLERGAN, INC. (US) | 1993-01-19 | — | — | US | claimed |
| WO-1992021349-A1 | COMBINATIONS OF ALPHA-2 ADRENERGIC AGONISTS WITH ALPHA-3 ANTAGONISTS FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 1992-12-10 | — | — | WO | claimed |
| EP-0399791-A1 | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure | ALLERGAN, INC (US) | 1990-11-28 | — | — | EP | claimed |
| EP-0086126-B1 | IMIDAZOLINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL APPLICATION | SYNTHELABO (FR) | 1985-07-24 | — | — | EP | claimed |
| US-4492709-A | VISION DEFECTX | SYNTHELABO (FR) | 1985-01-08 | — | — | US | disclosed |