Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595403 | 0.85 | ADRB1 (0.62) | ADRB1GRIN2BPOLBACHEDRD2 | |
| SCHEMBL9595026 | 0.80 | ADRB1 (0.66) | ADRB1GRIN2BSMN1; SMN2 | |
| SCHEMBL9595783 | 0.77 | ALDH1A1 (0.45) | ADRB1GRIN2BPOLBROCK2NPC1 | |
| SCHEMBL8781020 | 0.72 | DRD4 (0.60) | ADRB1POLBDRD2 | |
| SCHEMBL9594552 | 0.69 | SIGMAR1 (0.50) | GRIN2BPOLBACHEDRD2 | |
| SCHEMBL25154608 | 0.68 | DRD4 (0.46) | GRIN2BSMN1; SMN2 | |
| SCHEMBL25154267 | 0.68 | DRD4 (0.46) | GRIN2BSMN1; SMN2 | |
| SCHEMBL14578035 | 0.67 | ALDH1A1 (0.56) | GRIN2BACHESMN1; SMN2 | |
| SCHEMBL18618573 | 0.67 | SIGMAR1 (0.54) | — | |
| SCHEMBL21455307 | 0.67 | PKM (0.51) | POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491709-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-07-01 | — | — | EP | disclosed |
| WO-1991004250-A1 | 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-04-04 | — | — | WO | disclosed |