Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | LTA4H | P09960 | 8/20 | 0.75 |
| ▸ | PLA2G2A | P14555 | 8/20 | 0.75 |
| ▸ | HTR1D | P28221 | 6/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.66 |
| ▸ | HTR1B | P28222 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988545 | 0.87 | HTR1D (0.78) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| 5-Benzyloxytryptamine SCHEMBL2537373 | 0.87 | TRPM8 (1.00) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL27406721 | 0.87 | TRPM8 (0.77) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| 5-Benzyloxytryptamine SCHEMBL29785061 | 0.87 | TRPM8 (1.00) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL6388022 | 0.87 | POLB (0.78) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL29617411 | 0.86 | TRPM8 (0.76) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL29007183 | 0.86 | TRPM8 (0.76) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| 5-Benzyloxytryptamine SCHEMBL2540855 | 0.86 | LTA4H (1.00) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL24183187 | 0.85 | TRPM8 (0.74) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL6987351 | 0.85 | SLC6A4 (0.77) | TRPM8KDM4EMAPTLTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692102-B1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX INC (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20110165164-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110052589-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-7871619-B2 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20100247540-A1 | Methods and Compositions For Modulating Angiogenesis | CHEMOCENTRYX, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-7777009-B2 | Compositions for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090054630-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. | 2009-02-26 | — | — | US | disclosed |
| US-7442512-B2 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-7413866-B2 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1715892-A4 | METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS | CHEMOCENTRYX INC (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2005074645-A2 | METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS | CHEMOCENTRYX, INC. (US) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005044792-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2005-05-19 | — | — | WO | disclosed |
| US-20050074826-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2005-04-07 | — | — | US | disclosed |
| WO-2004108887-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2004-12-16 | — | — | WO | disclosed |
| EP-1461061-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | ChemoCentryx Inc (US) | 2004-09-29 | — | — | EP | disclosed |
| US-20040170634-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. (US) | 2004-09-02 | — | — | US | disclosed |
| US-20040018563-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX INC. (US) | 2004-01-29 | — | — | US | disclosed |
| US-20030124628-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CHEMOCENTRYX, INC. | 2003-07-03 | — | — | US | disclosed |
| WO-2003047420-A2 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CHEMOCENTRYX INC. (US) | 2003-06-12 | — | — | WO | disclosed |
| EP-1316801-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | Chemocentryx, Inc. (US) | 2003-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165164-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CXCR3, CXCR2, ACKR3 | TRPM8 2782/4885KDM4E 4712/4885MAPT 3785/4885 |
| US-20090054630-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CXCR3, CCR2, CCL2 | TRPM8 3522/4885KDM4E 4658/4885MAPT 3059/4885 |
| US-20110052589-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DISEASES AND CONDITIONS RELATED TO CHEMOKINE RECEPTORS | CXCR3, CXCR2, ACKR3 | TRPM8 2782/4885KDM4E 4712/4885MAPT 3785/4885 |
| US-20040170634-A1 | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors | CXCR3, CXCR2, ACKR3 | TRPM8 2782/4885KDM4E 4712/4885MAPT 3785/4885 |
| US-20100247540-A1 | Methods and Compositions For Modulating Angiogenesis | VEGFA, FLT4, PGF | TRPM8 4341/4885KDM4E 2964/4885MAPT 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.