Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9599300 | 0.88 | SMN1; SMN2 (0.40) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9598136 | 0.86 | SMN1; SMN2 (0.39) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4157574 | 0.86 | ENPP2 (0.39) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9599413 | 0.86 | L3MBTL1 (0.42) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9597646 | 0.85 | ENPP1 (0.41) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9597622 | 0.83 | ENPP1 (0.38) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9598810 | 0.82 | ENPP3 (0.44) | HTTSMN1; SMN2ALDH1A1MAPTENPP2 | |
| SCHEMBL8652435 | 0.81 | SMN1; SMN2 (0.43) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4635730 | 0.78 | ALDH1A1 (0.43) | HTTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9598092 | 0.78 | RAPGEF4 (0.49) | ALDH1A1MEN1KMT2AENPP2RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |